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MANF overexpression extends lifespan in flies We asked whether this change in MANF expression would impact age related phenotypes and longevity in flies Fig 2a k Fly ageing is accompanied by
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Characterization of MANF transgenic mouse model If MANF is indeed involved in the hypothalamic control of energy homeostasis changing its expression level in mice should lead to altered energy
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Early functional studies about MANF are focused on its role in Parkinson s disease PD as genetic knockdown or knockout of manf in zebrafish or fruit fly lead to defective development of the dopamine system Palgi et al 2009; Chen et al 2012 and administration of purified MANF protein or viral vectors expressing MANF has beneficial
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Induction of MANF in inflammatory diseases and rabbit antigen induced arthritis a The levels of MANF mRNA in SLE n = 65 and RA n = 63 patients were detected by real time qPCR
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